DC 3 Supercritical fluid chromatography-based approaches for the analysis and isolation of novel natural products from microbial producers

https://euraxess.ec.europa.eu/jobs/142803

The advertised doctoral position will be carried out at Saarland University over a period of 36 months. The recruited researcher will be supervised by Prof. Rolf Müller and Dr. Daniel Krug and work in the department of Pharmaceutical Biotechnology, led by Prof. Müller. The doctoral candidate will be registered for the PhD programme at Saarland University, Germany.

The project will focus on developing and applying supercritical fluid chromatography-based approaches for the analysis and isolation of novel natural products from microbial producers, both on an analytical (coupled to high-resolution MS) and a preparative scale. This technology not only allows for the isolation and analysis of complex natural products that could not be handled with common chromatographic approaches, but also reduces the amount of required organic solvents, thus making it a greener alternative.

The main working tasks of the advertised position are

(1) Development and validation of supercritical fluid chromatography-based analytical methods for isolation of novel natural products from microbial producers

(2) Expanding the exploitable chemical space of microbial extracts for the identification of novel natural products with intriguing bioactivities.

In the frame of the research project, short term (secondment) visits at other partners premises are envisioned. As per call requirements, candidate will spend at least half of the total contract time in a non-academic environment.