DC 5 Novel nanoformulations for oral delivery of nanovesicles by employing low emission green manufacturing technologies

https://euraxess.ec.europa.eu/jobs/139052

The advertised doctoral position will be carried out at NANOMOL Technologies SL over a period of 36 months. The recruited researcher will be supervised by Dr. Lidia Ferrer-Tasies and work in the Research and Development department, led by Dr. Lidia Ferrer-Tasies. The doctoral candidate will be registered for the PhD programme at the Autonomous University of Barcelona, Spain, and will be co-supervised by Dr. Elisabet González from Institute of Material Science of Barcelona (ICMAB) of Agencia Estatal Consejo Superior de Investigaciones Cientificas (CSIC).

NANOMOL Technologies is a Spanish SME delivering advanced solutions to obtain high-added-value products by particle technologies and nanoformulations. NANOMOL Technologies has already an operative contract analysis unit which is fully GMP compliant for the particle characterization of APIs and has already consolidated deep knowledge and understanding on particle size and shape analysis, complemented by a vast experience to characterize APIs, pharmaceutical intermediates and final formulations. Besides, Nanomol develops its proprietary robust green and sustainable DELOS platform, that uses compressed CO₂ as solvent, for design, engineering and production of nano-pharmaceuticals, being experienced in formulation development and scale-up to pilot plant using QbD approaches for several kinds of APIs (small molecules to biologics) for different therapeutic applications through several administration routes.

In this regard, the specific project will focus on preparation of liquid formulations for oral delivery based on lipid DELOS nanovesicles integrating active compounds. Process parameters will be explored to enhance the encapsulation of these compounds in DELOS nanovesicles. The influence of operational parameters and critical material attributes on CQAs will be evaluated following a QbD strategy. In vitro studies will be evaluated to study the suitability of DELOS nanovesicles prototypes for oral administration.

The main working tasks of the advertised position are:

(1) Established green drug delivery system manufacturing protocols by DELOS,

(2) Determination of interdependency of CQAs and process parameters,

(3) Encapsulation of actives to protect from degradation, improve its solubility, bioavailability and stability for oral delivery.

In the frame of the research project, short term (secondment) visits at other partners’ premises are envisioned. As per call requirements, candidate will spend at least half of the total contract time in a non-academic environment.